Make sure you have macports from macports.org. In a Terminal, execute: sudo port install boost sudo port install py27-pyside sudo port install py27-numpy sudo port install py27-opengl sudo port install py27-beautifulsoup4 sudo port install py27-pil sudo port install py27-py2app Execute 'make darwin' An madparts.app directory will be made in dist/ Compress this .app directory to distribute or just execute it as an osx app.